ⓘ Edgewood Arsenal human experiments. From 1948 to 1975, the U.S. Army Chemical Corps conducted classified human subject research at the Edgewood Arsenal facility ..


ⓘ Edgewood Arsenal human experiments

From 1948 to 1975, the U.S. Army Chemical Corps conducted classified human subject research at the Edgewood Arsenal facility in Maryland. The purpose was to study the effect of low-dose chemical warfare agents on military personnel, as well as to test protective clothing, pharmaceuticals and vaccines. Some of the studies were directed at psychochemical warfare and named the "Medical Research Volunteer Program". The MRVP was partially driven by the need for more effective enhanced interrogation techniques.

About 7.000 soldiers were used in the experiments, involving exposures to more than 250 different chemicals. Some of the subjects exhibited symptoms at the time of exposure to these agents but long-term follow-up was never provided. The experiments were abruptly terminated by the Army in late 1975 as questions were raised over the legality and ethics of such tests. Many official government reports and civilian lawsuits followed in the wake of the termination.

The chemical agents tested on subjects included chemical warfare agents and other related agents:

  • Anticholinesterase nerve agents and carbamate pesticides)
  • Irritants and riot control agents
  • Mustard agents
  • Alcohol and caffeine
  • Nerve agent antidotes including atropine and scopolamine
  • Psychoactive agents including LSD, PCP, cannabinoids, and BZ
  • Nerve agent reactivators, e.g. the common OP antidote 2-PAM chloride

1.1. History Background and rationale

After World War II, U.S. military researchers obtained formulas for the three nerve gases developed by the Nazis - tabun, soman, and sarin - and conducted studies on them at the US Army Edgewood Chemical Biological Center. These studies included a secret human subjects component at least as early as 1948, when "psychological reactions" were documented in Edgewood technicians. Initially, such studies focused solely on the lethality of the gases and its treatment and prevention. A classified report entitled "Psychochemical Warfare: A New Concept of War" was produced in 1949 by Luther Wilson Greene, Technical Director of the Chemical and Radiological Laboratories at Edgewood. Greene called for a search for novel psychoactive compounds that would create the same debilitating mental side effects as those produced by nerve gases, but without their lethal effect. In his words,

Throughout recorded history, wars have been characterized by death, human misery, and the destruction of property; each major conflict being more catastrophic than the one preceding it…I am convinced that it is possible, by means of the techniques of psychochemical warfare, to conquer an enemy without the wholesale killing of his people or the mass destruction of his property.

In the late 1940s and early 50s, the U.S. Army worked with Harvard anesthesiologist Henry K. Beecher at its interrogation center at Camp King in Germany on the use of psychoactive compounds mescaline, LSD, including human subject experiments and the debriefing of former Nazi physicians and scientists who had worked along similar lines before the end of the war. In the 1950s, some officials in the U.S. Department of Defense publicly asserted that many "forms of chemical and allied warfare as more humane than existing weapons. For example, certain types of psychochemicals would make it possible to paralyze temporarily entire population centers without damage to homes and other structures." Soviet advances in the same field were cited as a special incentive giving impetus to research efforts in this area, according to testimony by Maj. Gen. Marshall Stubbs, the Armys chief chemical officer.

General William M. Creasy, former chief chemical officer, U.S. Army, testified to the U.S. House of Representatives in 1959 that "provided sufficient emphasis is put behind it, I think the future lies in the psychochemicals." This was alarming enough to a Harvard psychiatrist, E. James Lieberman, that he published an article entitled "Psychochemicals as Weapons" in The Bulletin of the Atomic Scientists in 1962. Lieberman, while acknowledging that "most of the military data" on the research ongoing at the Army Chemical Center was "secret and unpublished", asserted that "There are moral imponderables, such as whether insanity, temporary or permanent, is a more humane military threat than the usual afflictions of war."


1.2. History The experiments

The Edgewood Arsenal human experiments took place from approximately 1948 to 1975 at the Medical Research Laboratories - which is now known as the U.S. Army Medical Research Institute of Chemical Defense USAMRICD - at the Edgewood Area, Aberdeen Proving Ground, Maryland. The experiments involved at least 254 chemical substances, but focused mainly on midspectrum incapacitants, such as LSD, THC derivatives, benzodiazepines, and BZ. Around 7.000 US military personnel and 1.000 civilians were test subjects over almost three decades. A concrete result of these experiments was that BZ was weaponized, although never deployed.

According to a DOD FAQ, the Edgewood Arsenal experiments involved the following "rough breakout of volunteer hours against various experimental categories":

An "Independent Study Course" for continuing medical education produced by the US Department of Veterans Affairs, Health Effects from Chemical, Biological, and Radiological Weapons October 2003, presents the following summary of the Edgewood Arsenal experiments:

Renewed interest led to renewed human testing by the Department of Defense DoD, although ultimately on a much smaller scale. Thus, between 1950 and 1975, about 6.720 soldiers took part in experiments involving exposures to 254 different chemicals, conducted at U.S. Army Laboratories at Edgewood Arsenal, MD. Congressional hearings into these experiments in 1974 and 1975 resulted in disclosures, notification of subjects as to the nature of their chemical exposures, and ultimately to compensation for a few families of subjects who had died during the experiments NAS 1993.

These experiments were conducted primarily to learn how various agents would affect humans NRC 1982. Other agencies including the CIA and the Special Operations Division of the Department of the Army were also reportedly involved in these studies NAS 1993. Only a small number of all the experiments done during this period involved mustard agents or Lewisite. Records indicate that between 1955 and 1965, of the 6.720 soldiers tested, only 147 human subjects underwent exposure to mustard agent at Edgewood NRC 1982.

According to the 1984 NRC review, human experiments at DoDs Edgewood Arsenal involved about 1.500 subjects who were experimentally exposed to irritant and blister agents including:

  • chloropicrin PS;
  • other ocular and respiratory irritants; and
  • riot control agents, e.g., CS;
  • mustard agents.
  • lachrymatory agents, e.g., CN;
  • Diphenylaminochlorarsine DM, Adamsite;

For example, from 1958 to 1973 at least 1.366 human subjects underwent experimental exposure specifically with the riot-control agent CS at Edgewood Arsenal NRC 1984. Of those involved in the experiments:

  • 1.073 subjects were exposed to aerosolized CS;
  • 180 subjects were exposed dermally;
  • 82 subjects had both skin applications and aerosol exposures; and finally
  • 31 subjects experienced ocular exposure via direct CS application to their eyes.

Most of these experiments involved tests of protective equipment and of subjects ability to perform military tasks during exposure.

Similarly, cholinesterase reactivators antidotes such as 2-PAM were tested on about 750 subjects. These agents are still used today as antidotes to organophosphorus nerve agent poisoning, including accidental poisoning by organophosphorus pesticides. About 260 subjects were experimentally exposed to various psychochemicals including phencyclidine PCP, and 10 related synthetic analogs of the active ingredient of cannabis NRC 1984. The NRC report also mentions human experiments involving exposure of 741 soldiers to LSD NRC 1984. Finally, from 1962 to 1972, a total of 123 irritant chemicals were tested on only two subjects each exposed using a wind tunnel NRC 1984. These irritant chemicals were selected for human testing following preliminary animal studies.

The "Independent Study Course" cites mainly a three-volume study by the Institute of Medicine 1982–1985 for its data and conclusions, Possible Long-Term Health Effects of Short-Term Exposure to Chemical Agents. Some additional information in the section cited from the Course was based on a 1993 IOM study, Veterans at Risk: Health Effects of Mustard Gas and Lewisite.

A significant omission from the Course summary above is the number of subjects on which BZ and related compounds were tested. According to the memoirs of James Ketchum, who also cites the IOM study for the data, "24 belladonnoid glycolates and related compounds" were "given to 1.800 subjects". The IOM study also concluded that "available data suggest that long-term toxic effects and/or delayed sequellae are unlikely" for this type of compound.

In the mid-1970s, in the wake of many health claims made regarding exposure to the agents, the U.S. Congress began investigations of possible abuse in experiments and of inadequate informed consent given to the soldiers and civilians involved.


1.3. History Scandal and termination

In September 1975, the Medical Research Volunteer Program was discontinued and all resident volunteers were removed from the Edgewood installation. The founder and director of the program, Dr Van Murray Sim, was called before Congress and chastised by outraged lawmakers, who questioned the absence of follow-up care for the human volunteers. An Army investigation subsequently found no evidence of serious injuries or deaths associated with the MRVP, but deplored both the recruiting process and the informed consent approach, which they characterized as "suggest possible coercion".


2.1. Aftermath Government reports

1982-85 IOM report The Institute of Medicine IOM published a three-volume report on the Edgewood research in 1982–1985, Possible Long-Term Health Effects of Short-Term Exposure to Chemical Agents.

The three volumes were:

  • Vol. 1, "Anticholinesterases and Anticholinergics" 1982.
  • Vol. 3, "Final Report: Current Health Status of Test Subjects" 1985
  • Vol. 2, "Cholinesterase Reactivators, Psychochemicals and Irritants and Vesicants" 1984

The National Academy of Sciences, which oversees the IOM, sent a questionnaire to all of the former volunteers that could be located, approximately 60% of the total. The lack of a detailed record hampered the investigation. The study could not rule out long-term health effects related to exposure to the nerve agents. It concluded that "Whether the subjects at Edgewood incurred these changes)

In the 1990s, the law firm Morrison & Foerster agreed to take on a class-action lawsuit against the government related to the Edgewood volunteers. The plaintiffs collectively referred to themselves as the "Test Vets".

In 2009 a lawsuit was filed by veterans rights organizations Vietnam Veterans of America, and Swords to Plowshares, and eight Edgewood veterans or their families against CIA, the U.S. Army, and other agencies. The complaint asked the court to determine that defendants’ actions were illegal and that the defendants have a duty to notify all victims and to provide them with health care. In the suit, Vietnam Veterans of America, et al. v. Central Intelligence Agency, et al. Case No. CV-09-0037-CW, U.S.D.C. N.D. Cal. 2009, the plaintiffs did not seek monetary damages. Instead, they sought only declaratory and injunctive relief and redress for what they claimed was several decades of neglect and the U.S. governments use of them as human guinea pigs in chemical and biological agent testing experiments.

The plaintiffs cited:

  • A deliberate destruction of evidence and files documenting their illegal actions, actions which were punctuated by fraud, deception, and a callous disregard for the value of human life.
  • A failure to secure informed consent and other widespread failures to follow the precepts of U.S. and international law regarding the use of human subjects, including the 1953 Wilson Directive and the Nuremberg Code.
  • The use of troops to test nerve gas, psychochemicals, and thousands of other toxic chemical or biological substances.
  • A refusal to satisfy their legal and moral obligations to locate the victims of experiments or to provide health care or compensation to them

On July 24, 2013, United States District Court Judge Claudia Wilken issued an order granting in part and denying in part plaintiffs motion for summary judgment and granting in part and denying in part defendants motion for summary judgment. The court resolved all of the remaining claims in the case and vacated trial. The court granted the plaintiffs partial summary judgment concerning the notice claim: summarily adjudicating in plaintiffs favor, finding that "the Army has an ongoing duty to warn" and ordering "the Army, through the DVA or otherwise, to provide test subjects with newly acquired information that may affect their well-being that it has learned since its original notification, now and in the future as it becomes available". The court granted the defendants motion for summary judgment with respect to the other claims.

On appeal in Vietnam Veterans of America v. Central Intelligence Agency, a panel majority held in July 2015 that Army Regulation 70-25 AR 70-25 created an independent duty to provide ongoing medical care to veterans who participated in U.S. chemical and biological testing programs. The prior finding held that the Army has an ongoing duty to seek out and provide" notice” to former test participants of any new information that could potentially affect their health.


3. Material Testing Program EA Edgewood Arsenal numbers

  • EA 1255 - S-butyl sarin
  • EA 1221 - O-isopentyl sarin
  • EA 1476 - A dimethylheptylpyran variant "red oil"
  • EA 2148-A - Phencyclidine PCP
  • EA 1677 - VS, a "V-series" nerve agent
  • EA 1653 - LSD in tartarate form
  • EA 1298 - Methylenedioxyamphetamine MDA, an analogue and active metabolite of MDMA
  • EA 1508 - VE
  • EA 1212 - Cyclosarin GF
  • EA 1285 - Tetraethyl pyrophosphate TEPP
  • EA 1729 - LSD in free base form
  • EA 1152 - Diisopropyl fluorophosphate DFP
  • EA 2233 - A dimethylheptylpyran variant
  • EA 1664 - Edemo VM
  • Eight individual isomers numbered EA-2233-1 through EA-2233-8
  • EA 1475 - Methylenedioxymethamphetamine
  • EA 2092 - Benactyzine
  • EA 1205 - Tabun GA
  • EA-1211 - GH
  • EA 1701 - VX
  • EA 1517 - VE
  • EA 1208 - Sarin GB
  • EA-1209 - Ethylsarin GE
  • EA 1210 - Soman GD
  • EA 5823 - Sarin GB as a binary agent from mixing OPA isopropyl alcohol+isopropyl amine + DF
  • EA 3834 - A BZ variant
  • EA 3528 - LSD in malleate form
  • EA 3580 - A BZ variant
  • EA 5365 - GV
  • EA 3167 - A BZ variant
  • EA 3443 - A BZ variant
  • EA 2277 - BZ "Substance 78" to Soviets
  • EA 3148 - A "V-series" nerve agent, Cyclopentyl S-2-diethylaminoethyl methylphosphonothiolate "Substance 100A" to Soviets
  • when his father was employed at Edgewood Arsenal Edgewood Arsenal human experiments Edgewood Chemical Activity Edgewood Chemical Biological Center U.S
  • Army Ordnance Training and Heritage Center Herman Goldstine Edgewood Arsenal human experiments Poplar Island Chesapeake Bay Maryland World War II Army
  • although not as much as other compounds such as 302196. Edgewood Arsenal human experiments EA - 3167 N - methyl - 3 - piperidyl benzilate N - ethyl - 3 - piperidyl
  • have also been synthesized under the codename HL - 031120. Edgewood Arsenal human experiments N - Methyl - 3 - piperidyl benzilate N - Ethyl - 3 - piperidyl benzilate
  • the United States Navy. From the 1950s to the 1970s, Edgewood Arsenal conducted experiments on human subjects with cannabis and its derivatives. One study
  • Incapacitating Chemical Agents During the Cold War 1955 - 1975 2006 Edgewood Arsenal human experiments David Rioch Khatchadourian, Raffi December 17, 2012 Operation
  • Harvey during the Air Raid on Bari Dugway sheep incident Edgewood Arsenal human experiments Operation LAC, Large Area Coverage 1958 test that dropped
  • investigated by the US military chemical weapons program in the Edgewood Arsenal experiments as possible non - lethal incapacitating agents. DMHP has three
  • without their knowledge or consent, at the Edgewood Arsenal in Maryland. Years after these experiments more than 1, 000 of these soldiers suffered from
  • MKUltra. In the same period, the US Army undertook the secret Edgewood Arsenal human experiments which grew out of the U.S. chemical warfare program and involved