ⓘ Race and health ..

Alcohol tolerance

Alcohol tolerance refers to the bodily responses to the functional effects of ethanol in alcoholic beverages. This includes direct tolerance, speed of recovery from insobriety and resistance to the development of alcoholism.

Common disease-common variant

The common disease-common variant hypothesis predicts that common disease-causing alleles, or variants, will be found in all human populations which manifest a given disease. Common variants are known to exist in coding and regulatory sequences of genes. According to the CD-CV hypothesis, some of those variants lead to susceptibility to complex polygenic diseases. Each variant at each gene influencing a complex disease will have a small additive or multiplicative effect on the disease phenotype. These diseases, or traits, are evolutionarily neutral in part because so many genes influence t ...

Isosorbide dinitrate/hydralazine

Isosorbide dinitrate/hydralazine is a fixed dose combination drug treatment specifically approved by the US FDA to be used to treat self-identified black people with congestive heart failure. It is a combination of hydralazine and isosorbide dinitrate. It is the first race-based prescription drug in the United States. The combination preparation is marketed in the United States under the trade name BiDil by Arbor Pharmaceuticals, Inc. which purchased the rights to market the drug in December 2011 from NitroMed.

Medical genetics of Jews

There are several autosomal recessive genetic disorders that are more common in ethnically Jewish populations, particularly Ashkenazi Jews, than the population as a whole. This is due to population bottlenecks that occurred relatively recently in the past as well as a practice of consanguineous marriage. These two phenomena lead to a decrease in genetic diversity and a higher likelihood that two parents will carry a mutation in the same gene and pass on both mutations to a child. The genetics of Ashkenazi Jews have been particularly well-studied, as the phenomenon affects them the most. Th ...