ⓘ Progressive disease or progressive illness is a disease or physical ailment whose course in most cases is the worsening, growth, or spread of the disease. This ..


ⓘ Progressive disease

Progressive disease or progressive illness is a disease or physical ailment whose course in most cases is the worsening, growth, or spread of the disease. This may happen until death, serious debility, or organ failure occurs. Some progressive diseases can be halted and reversed by treatment. Many can be slowed by medical therapy. Some cannot be altered by current treatments.

Though the time distinctions are imprecise, diseases can be rapidly progressive typically days to weeks or slowly progressive months to years. Virtually all slowly progressive diseases are also chronic diseases in terms of time course; many of these are also referred to as degenerative diseases. Not all chronic diseases are progressive: a chronic, non-progressive disease may be referred to as a static condition.

Progressive disease can also be a clinical endpoint i.e. an endpoint in a clinical trial.


1. Examples

There are examples of slowly and rapidly progressive diseases affecting all organ systems and parts of the body. The following are some examples of rapidly and slowly progressive diseases affecting various organ systems:

  • Joints: Both osteoarthritis and rheumatoid arthritis are slowly progressive forms of arthritis.
  • Eyes: Cataracts can be static or slowly progressive. Macular degeneration is slowly progressive, while retinal detachment is rapidly progressive.
  • Brain: Creutzfeldt–Jakob disease progresses rapidly compared to Alzheimers disease.
  • Lungs: Emphysema due to alpha-1 antitrypsin deficiency is a slowly progressive pulmonary disease.
  • Kidneys: Goodpastures syndrome is a rapidly progressive glomerulonephritis, while diabetic glomerulosclerosis is slowly progressive.
  • Pancreas: Type 1 diabetes mellitus involves rapidly progressive loss of insulin secretory capacity compared to type 2 diabetes mellitus, in which the loss of insulin secretion is slowly progressive over many years. MODY 2, due to GCK mutation, is a relatively static form of reduced insulin secretion.
  • Nerves: Essential tremor is a slowly progressive neurological disorder which is usually genetically passed down.
  • Progressive muscular atrophy PMA is a rare subtype of motor neuron disease MND that affects only the lower motor neurons. PMA is thought to account
  • New Zealand retail cooperative Progressive disease Progressive lens, a type of corrective eyeglass lenses Progressive Adventism, a sect of the Seventh - day
  • Progressive supranuclear palsy PSP is a degenerative disease involving the gradual deterioration and death of specific volumes of the brain. The condition
  • for Lafora Disease Epilepsy Foundation. Retrieved 2017 - 12 - 13. Lafora disease - OxfordJournals.org GeneReview NCBI NIH UW entry on Progressive Myoclonus
  • Slowly progressive diseases are also chronic diseases many are also degenerative diseases The opposite of progressive disease is stable disease or static
  • and hobbies. Moreover, in diseases such as Alzheimer s disease Pick s disease and Creutzfeldt - Jakob disease progressive deterioration of comprehension
  • mutations, in order to determine risk of transmission. The disease is typically progressive leading to fulminant liver failure and death in childhood
  • Progressive multifocal leukoencephalopathy PML is a rare and often fatal viral disease characterized by progressive damage - pathy or inflammation
  • Chronic progressive external ophthalmoplegia CPEO is a type of eye disorder characterized by slowly progressive inability to move the eyes and eyebrows
  • prominent seizure type. Several conditions can cause progressive myoclonic epilepsy. Unverricht - Lundborg disease Baltic myoclonus Myoclonus epilepsy and ragged