ⓘ Clinical research ..

Active placebo

An active placebo is a placebo that produces noticeable side effects that may convince the person being treated that they are receiving a legitimate treatment, rather than an ineffective placebo.

Adverse event

An adverse event is any untoward medical occurrence in a patient or clinical investigation subject administered a pharmaceutical product and which does not necessarily have a causal relationship with this treatment. An adverse event can therefore be any unfavourable and unintended sign, symptom, or disease temporally associated with the use of a medicinal product, whether or not related to the medicinal product. AEs in patients participating in clinical trials must be reported to the study sponsor and if required could be reported to local ethics committee. Adverse events categorized as "s ...

Analysis of clinical trials

The analysis of clinical trials involves many related topics including: the choice and definition of analysis sets, appropriate accounting for the treatment assignment process, and appropriate data presentation. the choice of an appropriate statistical model for the type of data being studied, handling of multiple comparisons or endpoints, accounting for interim analyses and trial adaptations, handling of missing data, the choice of an estimand measure of effect size of interest that is closely linked to the objectives of the trial, One basic guidance document on this topic is the Internat ...

Approved drug

An approved drug is a preparation that has been validated for a therapeutic use by a ruling authority of a government. This process is specific by country.

Assay sensitivity

Assay sensitivity is a property of a clinical trial defined as the ability of a trial to distinguish an effective treatment from a less effective or ineffective intervention. Without assay sensitivity, a trial is not internally valid and is not capable of comparing the efficacy of two interventions.

Biodistribution

Biodistribution is a method of tracking where compounds of interest travel in an experimental animal or human subject. For example, in the development of new compounds for PET scanning, a radioactive isotope is chemically joined with a peptide. This particular class of isotopes emits positrons. When ejected from the nucleus, positrons encounter an electron, and undergo annihilation which produces two gamma rays travelling in opposite directions. These gamma rays can be measured, and when compared to a standard, quantified.

                                     

ⓘ Clinical research

  • disease. Clinical research is different from clinical practice. In clinical practice established treatments are used, while in clinical research evidence
  • as an overview of and topical guide to clinical research Clinical research is the aspect of biomedical research that addresses the assessment of new pharmaceutical
  • A clinical research associate CRA also called a clinical monitor or trial monitor, is a health - care professional who performs many activities related
  • The phases of clinical research are the steps in which scientists do experiments with a health intervention in an attempt to find enough evidence for
  • Clinical Cancer Research is a peer - reviewed medical journal on oncology, including the cellular and molecular characterization, prevention, diagnosis
  • Clinical research ethics are the set of relevant ethics considered in the conduct of a clinical trial in the field of clinical research It borrows from
  • Clinical trials are experiments or observations done in clinical research Such prospective biomedical or behavioral research studies on human participants
  • A Clinical Research Coordinator CRC is a person responsible for conducting clinical trials using good clinical practice GCP under the auspices of a
  • Alcoholism: Clinical and Experimental Research is a scientific journal covering research concerning alcohol abuse and its treatment. It is published by
  • Clinical Center is a hospital solely dedicated to clinical research at the National Institutes of Health campus in Bethesda, Maryland. The Clinical Center
  • biologic assay development, commercialization, preclinical research clinical research clinical trials management, and pharmacovigilance. CROs are designed
  • Clinical Medicine Research is an open - access, peer - reviewed, academic journal of clinical medicine published by the Marshfield Clinic Research Foundation